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Molecular pathology in anatomic pathology practice: a review of basic principles | Read by QxMD
Anthony A. More than a million of different probes can be synthesized on an array with Affymetrix's Genechip technology with a detection limit of one to ten copies of mRNA per well. By utilizing DNA and RNA sequencing to do cancer diagnostics, technology in the field of molecular diagnostics tools will develop better. Although NGS throughput and price have dramatically been reduced over the past 10 years by roughly fold, we remain at least 6 orders of magnitude away from performing deep sequencing at a whole genome level.
Molecular diagnostics tool can be used for cancer risk assessment. It is useful to analyze people when they do not show obvious symptoms and thus can detect cancer at early stages. For example, the ColoGuard test may be used to screen people over 55 years old for colorectal cancer. Their technology can inform patients to seek chemotherapy when necessary by examining the RNA expression levels in breast cancer biopsy tissue. With rising government support in DNA molecular diagnostics, it is expected that an increasing number of clinical DNA detection assays for cancers will become available soon.
Currently, research in cancer diagnostics are developing fast with goals for lower cost, less time consumption and simpler methods for doctors and patients. From Wikipedia, the free encyclopedia.
Molecular diagnostics uses techniques such as mass spectrometry and gene chips to capture the expression patterns of genes and proteins. Main articles: Assay and Biological assay. See also: Category:Tests during pregnancy. Main article: Pharmacogenomics. See also: Pathogenomics. See also: Screening medicine and Genetic testing. See also: Tumor metabolome. Biology portal Technology portal Medicine portal. Expert Review of Molecular Diagnostics. The New England Journal of Medicine. Application to prenatal diagnosis of beta 0 thalassemia in Sardinia".
Predominance of minor immunoglobulin G subclasses in rheumatoid arthritis". The Journal of Clinical Investigation. Differences in monocyte phenotypes induced by cultivation on glass or on collagen". The Journal of Experimental Medicine. The Journal of Molecular Diagnostics.
Molecular pathology in anatomic pathology practice: a review of basic principles
Balkan Journal of Medical Genetics. Retrieved 13 June The Wall Street Journal. Retrieved 15 June The Washington Post. Detailing the various options available and what each requires". Retrieved 4 September FDA may be considering more restrictive approach with research use only assays". Design World. Retrieved 7 November Laboratory Medicine. Advanced Drug Delivery Reviews. Trends in Molecular Medicine. ESMO Open.
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